Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.

Pontificia Universidad Catolica de Chile50 enrolled

Overview

The purpose of this randomized clinical trial is to evaluate the effect of acute arterial hypertension maintained during surgery on morphine's requirements in patients undergoing laparoscopic cholecystectomy

The high arterial blood pressure has been correlated with an increase in pain threshold in animal and humans. One of the explanations to this phenomenon is a baroreceptor activity and vasopressin release at the level of spinal cord dorsal horn and hypothalamus. As far as we know, there is only one study about the effect of chronic hypertension on postoperative pain and none with acute hypertension. We therefore decided to conduct a randomized controlled trial to evaluate the effect of acute hypertension on postoperative morphine's requirements.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Hypertensive Disease Pain, Postoperative

Interventions

SBP 20-30% over baselineOTHER

Patients were assigned to receive a phenylephrine infusion in order to maintain systolic blood pressure (SBP) 20% to 30% over the baseline. The upper limit of systolic blood pressure is 165 mmHg.

SBP 20-30% under baselineOTHER

Patients were assigned to receive a phenylephrine infusion in order to maintain systolic blood pressure (SBP) 20% to 30% below the baseline. The lower limit of systolic blood pressure is 75 mmHg

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiology patient classification status(ASA) I-II * Between 20 and 60 years of age * Programed for elective laparoscopic cholecystectomy Exclusion Criteria: * History of arterial hypertension * Baseline blood pressure over 139/89 * Use of opioids and any analgesic drug during the last 24 hours before surgery * Chronic use of nonsteroidal antiinflammatory * BMI \> 34.9 * History of drug or alcohol abuse * Use of medications that interfere in the central nervous system * Adverse reactions to the drugs used in the study * Pregnancy

Locations (1)

Hospital Clinico Pontificia Universidad Catolica

Santiago, Santiago Metropolitan, Chile

Outcomes

Primary Outcomes

Morphine requirement post laparoscopic cholecystectomy

Measure of morphine consumption during the first 24 postoperative hours in patients undergoing laparoscopic cholecystectomy.

Time frame: First 24 hours postoperative

Secondary Outcomes

Effects of acute hypertension in pain scores

Time frame: First 24 hours postoperative

Data from ClinicalTrials.gov

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