The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA

Thammasat University60 enrolled

Overview

The purpose of this study is to determine the periarticular multimodal drug injection has more efficacy for controlling pain after TKA than single anaesthetic drug injection.

Many studies have to determine the efficacy of periarticular multimodal drug injection or single local anaesthetic drug comparing with placebo for pain controlled in TKA. But in this study would like to determine which one of both drugs are more efficacy. In multimodal drug injection consist of levobupivacaine, morphine, ketorolac and epinephrine while single anaesthetic drug has levobupivacaine and epinephrine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain

Interventions

single anaesthetic drugDRUG

inject periarticular tissue of the knee after implantation

multimodal drug injectionDRUG

inject periarticular tissue of the knee

Eligibility

Sex: ALLMin age: 50 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * primary osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty * age 50-85 years old Exclusion Criteria: * unable to perform spinal anaesthesia * history of drug allergies; local anaesthesia, Non-steroidal anti-inflammatory drugs, morphine, epinephrine * cognitive function impairment * renal impairment (creatinine clearance \< 30 mL/min) * liver impairment, gastrointestinal bleeding

Locations (1)

department of orthopaedic surgery, Faculty of medicine, Thammasat university

Khlong Luang, Changwat Pathum Thani, Thailand

Outcomes

Primary Outcomes

pain score

pain score at rest and activity between 2 groups every 4 hours until 48 hours after surgery

Time frame: 48 hour after surgery

Secondary Outcomes

time to request analgesic drug

time when patient request morphine from patient controlled analgesia after intra-operative drug injection

Time frame: 48 hours

Data from ClinicalTrials.gov

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