The Effect of Dexmedetomidine in Intraocular Pressure During Robot-Assisted Laparoscopic Radical Prostatectomy

Yonsei University70 enrolled

Overview

Intraocular pressure is significantly increase during robot-assisted laparoscopic radical prostatectomy which is performed in a steep trendelenburg position at prolonged timeds of pneumoperitoneum. Threrefore we decided to evaluate the effect of dexmedetomidine in intraocular pressure during roboti-assisted laparoscopic radical prostatectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Steep Trendelenburg Position With Penumoperitoneum in Robot Assisted Laparoscopic Prostatectomy

Interventions

DexmedetomidineDRUG

salineDRUG

Eligibility

Sex: MALEMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ASA class I-II 2. obtaining written informed consent from the parents 3. aged 20-70 years who were undergoing robot- assited laparoscopic prostatectomy Exclusion Criteria: 1. eye surgery prevoiusly 2. unstable angina or congestive heart failure 3. concomittant eye disease (glaucoma, diabetic retinophaty, cataract, retinal detachment) 4. high intraocular pressure over 30mmHg after screening test. 5. uncontrolled hypertension (diastolic bp\>110mmHg) 6. bradycardia under 60bpm 7. Ventricular conduction abnormality 8. hepatic failure 9. renal failure 10. drug hyperactivity 11. neurological or psychiatric illnesses 12. mental retardation 13. patients who can't read the consent form due to illiterate or foreigner

Outcomes

Primary Outcomes

Influence of dexmedetomidine in intraocular pressure during robot-assisted laparoscopic prostatectomy.

T0: Pre-induciton T1: 5min after anesthesia induction T2: 5 min after establish pneumoperitoneum T3: 15min after steep trendelenburg position T4: 30min after steep trendelenburg position T5: 45min after steep trendelenburg T6: 60min after steep trendelenburg T7: 75min after steep trendelenburg T8: 5min after returning to horizontal position T9: operation end T10: 5min after tracheal extubation T11: 60min after tracheal extubation

Time frame: change of intraocular pressure from T0 to T11 for 60mins

Data from ClinicalTrials.gov

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