Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic

University Hospital, Strasbourg, France8 enrolled

Overview

The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during a short constant load exercise in 4 conditions : * normoxia * hypoxia * hypercapnia * association hypoxia and hypercapnia

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Vascular Sensibility in Hypoxia Hypercapnia Hypoxia and Hypercapnia

Interventions

Hypercapnia inhalation (Altitrainer NP 190)DEVICE

Hypercapnia inhalation using an Altitrainer NP 190

Hypoxia and hypercapnia (Altitrainer NP 190)DEVICE

Hypoxia and hypercapnia inhalation using an Altitrainer NP 190

Hypoxia inhalation (Altitrainer NP 190)DEVICE

Hypoxia inhalation using an Altitrainer NP 190

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * healthy male * exercise capacity between 100 and 130 % of theorical values Exclusion criteria: * smoker * headache * impossibility to perform an exercise test * no tricuspid regurgitation on the echocardiography

Locations (1)

Service de Physiologie et d'Explorations Fonctionnelles, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Outcomes

Primary Outcomes

Systolic Artery Pulmonary Pressure(sPAP) (echocardiography, Cardiac output (impedancemetry), Cardiorespiratory parameters

At rest and during exercise for each condition

Time frame: at the end of the 30th minutes constant load exercise

Secondary Outcomes

Dyspnea and muscle leg discomfort using a Borg Scale

In each conditions at rest and during exercise

Time frame: at the end of the 30th minutes constant load exercise

Data from ClinicalTrials.gov

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