Evaluate the Efficacy and Safety of ON101 Cream for the Treatment of Chronic Diabetic Foot Ulcers

Inclusion Criteria 1. Has signed a written informed consent prior to the first study evaluation; 2. Male or female is at least 20 and \< 80 years of age; 3. Diabetes mellitus (type 1 or 2) with an HbA1c \< 12.0% measured during screening or within three months prior to randomization; 4. An ankle brachial index on the target limb at least 0.8 measured during screening or within three months prior to randomization; 5. The target ulcer must have the following characteristics: * Grade 1 or 2 per Wagner Ulcer Classification System; * No higher than the ankle; * No active infected; * A cross-sectional area of between 1 and 25 cm2 post-debridement; * Present for at least 4 weeks before randomization; 6. If female and of childbearing potential has a negative pregnancy test and is not breastfeeding at screening visit; 7. Able and willing to attend the scheduled visits and comply with study procedures. Exclusion Criteria: 1. Presence of necrosis, purulence or sinus tracts that cannot be removed by debridement; 2. Acute Charcot's neuroarthropathy as determined by clinical and/or radiographic examination; 3. Has undergone revascularization procedure aimed at increasing blood flow in the treatment target limb \< 4 weeks prior to randomization; 4. Poor nutritional status defined as an albumin \< 2.5 g/dL; 5. Aspartate Aminotransferase(AST, GOT) and/or Alanine Aminotransferase(ALT, GPT) \>3 x the normal upper limit; 6. Serum Creatinine \>2 x the normal upper limit; 7. Treatment with immunosuppressive or chemotherapeutic agents, radiotherapy or systemic corticosteroids less than 4 weeks before randomization; 8. Use of any investigational drug or therapy within the 4 weeks prior to randomization; 9. A psychiatric condition (e.g., suicidal ideation), current or chronic alcohol or drug abuse problem, determined from the subject's medical history, which, in the opinion of the Investigator, may pose a threat to subject compliance; 10. Judged by the investigator not to be suitable for the study for any other reason.