The Effect of Inhalation Agent on the QTc Interval During Liver Transplantation: Sub Study (NCT01886664)

Seoul National University Hospital52 enrolled

Overview

The purpose of this study is to assess the effects of inhalation agent on corrected QT interval duration during liver transplantation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anesthesia, General

Interventions

SevofluraneDRUG

DesfluraneDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * elective liver transplantation Exclusion Criteria: * age \< 18, age \> 65 * patient refusal * re-transplantation

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

corrected QT interval (QTc interval)

up to 10 minutes after tracheal intubation, up to 60 minutes after reperfusion, at 10 minutes after hepatectomy, at 10 minutes after biliary anastomosis, at skin closure, at the arrival on ICU, on postoperative day 1.

Time frame: up to postoperative day 1 after surgery

Secondary Outcomes

proportion of patients whose QTc interval is more than 450 ms for men and 470 ms for women

Time frame: up to postoperative day 1 after surgery

proportion of patients who have more than 500 ms of QTc interval

Time frame: up to postoperative day 1 after surgery

Tp-e interval

Time frame: up to postoperative day 1 after surgery

Data from ClinicalTrials.gov

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