Exercise and Severe Depression: Clinical and Biological Analysis

Hospital de Clinicas de Porto Alegre50 enrolled

Overview

The study aimed to evaluate the use of exercise as a complementary strategy to treat severe major depression in inpatients. Hypothesis: Exercise can be used as a safe and efficacious complimentary strategy in severe depressed inpatients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Depression

Interventions

ExerciseOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Major Depressive Disorder according to M.I.N.I (DSM-IV) criteria American Psychiatry Association(1994) * score of 25 or more on Hamilton-17 * not being involved in other physical activity programs during the hospitalization * aged between 18 and 60 years * being able to read, understand, and provide written informed consent Exclusion Criteria: * have three or more cardiovascular risk factors according to Physical Activity Readiness Questionnaire (PAR-Q) * are unable to exercise due other clinical condition * have diagnosis of Schizophrenia, Bipolar disorder or current use of alcohol or other drugs according to M.I.N.I DSM-IV criteria American Psychiatry Association(1994) * if they are taking beta-blocking medications

Locations (1)

Hospital de Clincas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Outcomes

Primary Outcomes

Depressive symptoms

Hamilton 17 for depression

Time frame: 2 weeks of hospitalization (14 days)

Secondary Outcomes

Quality of Life

WHOQOL-BREF

Time frame: Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks)

Brain-Derived Neurotrophic Factor(BDNF)

Time frame: Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks)

Thiobarbituric acid reactive substances(TBARS)

Time frame: Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks)

Depressive symptoms at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks)

Hamilton Scores at discharge

Time frame: Discharge

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.