Changes in Liver Steatosis After Switching to Raltegravir in HIV/HCV Coinfection

Inclusion Criteria: 1. Each subject must be willing and able to provide written informed consent for the trial. 2. Each subject must be ≥ 18 years of age. 3. Each subject must be male or non-pregnant, non-breastfeeding female 4. Each subject must have diagnosis of HIV infection. 5. Each subject must have concomitant coinfection by HCV as shown by detectable plasma HCV RNA. 6. Each subject must have stable treatment with EFV plus two nucleoside analogs for ≥24 weeks. 7. Each subject must have at least 2 documented plasma HIV RNA \<50 copies/ml during the last 24 weeks, as observed in, at least, two clinical visits. 8. Each subject must have HS involving more than 10% of hepatocytes, as determined by a CAP measurement ≥238 dB/m. 9. Each sexually active female subject of child-bearing potential must agree to use a medically accepted method of contraception while receiving protocol-specified medication and for 3 months after stopping the medication.Medically accepted methods of contraception include condoms (male or female) with or without a spermicidal agent, diaphragm or cervical cap with spermicide, medically prescribed IUD, inert or copper-containing IUD, hormone releasing IUD, systemic hormonal contraceptive, and surgical sterilization (eg,hysterectomy or tubal ligation).Postmenopausal women are not required to use contraception.Postmenopausal is defined as at least 12 consecutive months without a spontaneous menstrual period. 10. Each sexually active male subject with a female partner(s) of child-bearing potential must also provide written informed consent to provide information regarding any pregnancy. 11. Average daily alcohol intake lower than 50 g for men and 40 g for women. Exclusion Criteria: 1. The subject has an allergy/sensitivity to investigational product or its/their excipients. 2. The female subject is nursing. 3. The female subject is pregnant or intending to become pregnant. 4. History of ARV failure or documented resistance. 5. Baseline resistance to EFV or to any of the nucleoside analogues inhibitors in the regimen. 6. The subject has any clinically significant condition or situation, other than the condition being studied that, in the opinion of the investigator, would interfere with the trial evaluations or optimal participation in the trial. 7. The subject has active AIDS-defining event (CDC-C) within 24 weeks before screening. 8. The subject is candidate for therapy against HCV infection during the 48 week trial period in the opinion of the investigator. 9. The subject has a history of malignant neoplasia. 10. Active illicit drug use or any other condition that may compromise the study drug adherence in the opinion of the investigators. 11. The subject has used any investigational drugs within 30 days of Baseline. 12. A subject who has participated in any other clinical trial within 30 days,inclusive, of signing the informed consent form of the current trial. 13. The subject or a family member is among the personnel of the investigational or SPONSOR staff directly involved with this trial.