Noninvasive Positive Pressure Ventilation for Difficult Weaning in Tracheotomy Patients

N/ACompletedNCT01900990

Chongqing Medical University32 enrolled

Overview

The investigators adopt Noninvasive Positive Pressure Ventilation for weaning in tracheotomy patients innovatively. The investigators randomly allocate the subjects into two groups. One group is weaned by traditional strategy. The other one is weaned by Noninvasive Positive Pressure Ventilation by plugging the tracheotomy tube and deflating the cuff.

The investigators adopt Noninvasive Positive Pressure Ventilation for weaning in tracheotomy patients innovatively .If patients'conditions met our defined criterions, the investigators randomly allocate two groups. One group adopts traditional weaning strategy, the other adopts Noninvasive Positive Pressure Ventilation. If patients' condition deteriorated in group two, the investigators turned them to invasive positive pressure ventilation, until patients adapted in a satisfactory condition, the investigators shift them into Noninvasive Positive Pressure Ventilation. The investigators will extubate the tracheotomy tube, if patients are received Noninvasive Positive Pressure Ventilation more than 24 to 48 hours. After extubation, the investigators try to wean Noninvasive Positive Pressure Ventilation. Successful wean is defined weaning mechanical ventilation more than 48 hours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Respiratory Failure

Interventions

Noninvasive ventilation weaningDEVICE

We adopt Noninvasive Positive Pressure Ventilation in tracheotomy patients by capping the tracheotomy tube and deflating the cuff

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥ 18 years * tracheotomy mechanical ventilation patients Exclusion Criteria: * pregnancy * respiratory and hemodynamic instability * Recent oral，nasal，facial or cranial trauma or surgery * contra-indications for nasal or facial mask (facial skin lesions,...) * recent history of upper gastro-intestinal surgery * recent history of myocardial infarction * unconscious patients * non cooperative patient

Locations (2)

The First Affiliated Hospital ,Chongqing Medical Univercity

Chongqing, Chongqing Municipality, China

The First Affiliated Hospital ,Chongqing Medical Univercity

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

Main end-point defined as total duration of mechanical ventilation

The total duration of mechanical ventilation was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months.