Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), as well as patient satisfaction for these two muscle relaxants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
105
Anaesthesia was induced and maintained with propofol (1-2 mg/kg) and remifentanil (0.5 µg/kg). The study arm was immobilized and a dual electrode for peripheral nerve stimulation was placed over the ulnar nerve near the wrist. Neuromuscular monitoring was performed with accelerometry.The patients received succinycholine according to the study group.
Anaesthesia was induced and maintained with propofol (1-2 mg/kg) and remifentanil (0.5 µg/kg). The study arm was immobilized and a dual electrode for peripheral nerve stimulation was placed over the ulnar nerve near the wrist. Neuromuscular monitoring was performed with accelerometry.The patients received rocuronium/sugammadex according to the study group.
Dr. Horst Schmidt Kliniken
Wiesbaden, Germany
Intubating condition
scoring system proposed for Good Clinical Research Practice using the following variables: conditions of inserting rigid bronchoscope, vocal cord position, and coughing
Time frame: After induction of general anaesthesia (after 3-5 minutes)
Fasciculations
Fasciculations were graded by the investigator on the following four-point scale 0 = no fasciculations 1. = mild, fine fasciculations of the eyes, neck, face or fingers, without limb movement 2. = moderate fasciculations occurring at more than two sites, or obvious limb movement 3. = vigorous or severe, sustained and widespread fasciculations in the trunk and limbs
Time frame: After application of the neuromuscular blocking agent (after 3-5 min)
Postoperative Myalgia (POM)
The severity of POM was measured using a four-point scale 0 = no myalgia 1. = minor pain limited to one area of the body 2. = muscle pain or stiffness noticed spontaneously by the patient, which may have required analgesic therapy 3. = generalized, severe, or incapacitating discomfort
Time frame: 72 Hours after Intervention
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Anaesthesia was induced and maintained with propofol (1-2 mg/kg) and remifentanil (0.5 µg/kg). The study arm was immobilized and a dual electrode for peripheral nerve stimulation was placed over the ulnar nerve near the wrist. Neuromuscular monitoring was performed with accelerometry.The patients received rocuronium according to the study group.