Dose-ranging Study of Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Prevention of Complications of Early Decompensated Liver Cirrhosis

Inclusion Criteria: * Diagnosis of liver cirrhosis and documented ascites. * Model End Stage Liver Disease (MELD) score of at least 12, MELD Na of at least 12, or Child-Pugh B (score of 7 - 9). * If applicable, has a close family or other personal contacts who can provide continuing oversight to the patient and will be available to the patient during the conduct of the trial. * If female of childbearing potential, have a negative serum pregnancy test at study start and agree to use an acceptable method of contraception during the study. Exclusion Criteria: * History of a major psychiatric disorder including uncontrolled major depression or controlled or uncontrolled psychoses within the past 24 months prior to study start. * History of alcohol abuse or substance abuse within the past 3 months prior to study start. * Documented cholestatic liver disease such as primary sclerosing cholangitis. * Had prophylactic variceal banding within 2 weeks or is scheduled to undergo prophylactic banding during the study. * Diagnosed with an infection for which the patient is currently taking oral or parenteral antibiotics. * Significant hypovolemia, or any electrolyte abnormality that can affect mental function (eg, serum sodium \< 125 mEq/L, serum calcium \> 10 mg/dL). * Severe hypokalemia, defined as serum potassium concentration \< 2.5 mEq/L. * Anemic, defined as hemoglobin concentration ≤ 8 g/dL. * Renal insufficiency with a creatinine of ≥ 1.5 mg/dL. * Presence of intestinal obstruction or inflammatory bowel disease. * Uncontrolled Type 1 or Type 2 diabetes. * History of seizure disorders. * Unstable cardiovascular or pulmonary disease, categorized by a worsening in the disease condition that requires a change in treatment or medical care within 30 days of study start. * Active malignancy within the last 5 years (exceptions: basal cell carcinomas of the skin, or if female, in situ cervical carcinoma that has been surgically excised). * Has hepatocellular carcinoma. * Known human immunodeficiency virus, varicella, herpes zoster, or other severe viral infection within 6 weeks of study start. * Positive stool test for Yersinia enterocolitica, Campylobacter jejuni, Salmonella, Shigella, ovum and parasites, and/or Clostridium difficile (C. difficile); determined during the screening period prior to study start. * History of tuberculosis infection and/or has received treatment for a tuberculosis infection. * History of hypersensitivity to rifaximin, rifampin, rifamycin antimicrobial agents, or any of the components of rifaximin soluble solid dispersion. * Used any investigational product or device, or participated in another research study within 30 days prior to study start.