Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

N/ACompletedNCT01905345

University of Zurich30 enrolled

Overview

Randomised training intervention. Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell Sarcopenia Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible. Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation

Interventions

Eligibility

Sex: MALEMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: -male * no fever at the beginning and during the study * between 60 years and 75 years * non smokers * no known cardiovascular and orthopaedic problems * no cardiac pacemaker * fulfilling the health criteria Exclusion criteria: -female * fever or cold at the beginning or during the study * non MRI compatible metal implants * under 60 years or over 75 years * smoker * cardiovascular or orthopaedic problems * cardiac pacemaker * not fulfilling the health criteria

Outcomes

Primary Outcomes

Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes

Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain \[um\^2\], myonuclear number \[%\] in response to consecutive training regimes

Time frame: participants will be followed for the duration of training period, an expected average of 7 months