Sensory gating is defined as the automatic process of inhibiting brain response to repeated auditory sounds. Infants who brains respond similarly to two identical sounds presented about 1/2 second apart are more likely to have later problems with attention than infants who suppress response to the second sound. This study will examine whether providing a nutritional supplement, phosphatidylcholine, for two months in infancy will result in an increased likelihood of developing more robust sensory gating.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
phosphatidylcholine concentrate 700 mg twice per day
placebo manufactured look like phosphatidylcholine concentrate dosed at 1.2 ml twice per day
University of Colorado Denver
Aurora, Colorado, United States
Ratio of P50 auditory sensory gating
In an auditory evoked potential paradigm while in active sleep (the infant equivalent of rapid eye movement sleep) with two identical sounds presented 500 ms apart, the ratio of the amplitude of the P50 response to the second sound divided by the amplitude of the P50 response to the first sound.
Time frame: 8 weeks post initiation of treatment
Incidence of adverse events
Percentage of infants with adverse events
Time frame: 4 weeks and 8 weeks after initiation of intervention
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