Impact of a Non-Drug Choice on Cocaine Reinforcement

Early Phase 1CompletedNCT01906346

Joshua A. Lile, Ph.D.9 enrolled

Overview

Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate self-administration procedures and a non-drug alternative reinforcer, which is hypothesized to reduce the reinforcing effects of cocaine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Cocaine Dependence

Interventions

CocaineDRUG

Three active doses of cocaine will be made available for self-administration during experimental sessions.

PlaceboDRUG

Placebo cocaine will be made available for self-administration during experimental sessions.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cocaine dependence, otherwise healthy Exclusion Criteria: * Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease

Locations (1)

Laboratory of Human Behavioral Pharmacology

Lexington, Kentucky, United States

Outcomes

Primary Outcomes

The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative

The reinforcing effects of cocaine were determined using a modified progressive ratio procedure in which subjects made 9 choices between each available cocaine dose and one of three money alternatives.

Time frame: 9 choice trials per cocaine dose level with each trial separated by 30 minutes

Data from ClinicalTrials.gov

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