Dopaminergic Function and Food Reward

N/ACompletedNCT01906411

University Hospital Tuebingen36 enrolled

Overview

The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity. This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Adiposity Weight Loss

Interventions

Dopamine depletion vs. Balanced aminoacid drinkDIETARY_SUPPLEMENT

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * female * healthy Exclusion Criteria: * fMRI contraindications * claustrophobia

Locations (1)

University Clinic of Tuebingen, MEG Center

Tübingen, Germany

Outcomes

Primary Outcomes

Differential brain functions in the dopaminergic reward system

differential brain fuctions will be measured by blood oxygen level dependent effect.

Time frame: 4 hours after intake of the dopamine depletion or balanced aminoacid drink

Secondary Outcomes

amino acid level changes due to dopamine depletion

Time frame: 4 hours after intake of the dopamine depletion or balanced aminoacid drink

Data from ClinicalTrials.gov

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