Sub-threshold Pacing to Prevent Pacemaker-induced Ventricular Tachycardia

N/ACompletedNCT01906775

Johannes Gutenberg University Mainz550 enrolled

Overview

Implantable cardioverter defibrillators (ICD) may have the capacity to provoke or worsen ventricular tachyarrhythmias (VT). It has been reported that ICD shocks by itself can increase mortality. This study aimed to determine the role of back-up pacing-induced VT (PIT) to the overall ICD shock burden by avoiding pause-related ventricular back-up pacing by programming the pacing output to a sub-threshold level for ineffective pacing.

Study Type

OBSERVATIONAL

Enrollment

550

Conditions

Ventricular Tachyarrhythmias ICD Shock Therapy ICD Shock Burden

Interventions

Programming the pacemaker output for ventricular back-up pacing to a sub-threshold levelOTHER

Programming the pacemaker output for ventricular back-up pacing to a sub-threshold level to achieve an ineffective pacing output

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 years * implanted ICD * occurrence of pacemaker-induced VT Exclusion Criteria: * documentation of pause-related syncope * AV block * sick-sinus syndrome * younger than 18 years

Locations (1)

University Hospital Mainz, II. Medical Clinic, Dept. of Electrophysiology

Mainz, Germany

Outcomes

Primary Outcomes

Occurrence of VT requiring ICD shock

Patients were followed-up for the occurrence of ventricular tachycardia requiring ICD shock therapy

Time frame: 48 months follow-up

Secondary Outcomes

Type of arrhythmia / Number of arrhythmia

Analysis of the number and the types of recurrent arrhythmias requiring ICD shock termination

Time frame: 48 months

Data from ClinicalTrials.gov

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