Strategies for myocardial protection during open heart surgeries are desired. Several experimental studies have shown beneficial effects of remote ischemic preconditioning (RIPC). The underlying mechanisms are not totally understood. This study intends to evaluate molecular mechanisms involved with RIPC on myocardium of patients underwent open heart surgeries.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
120
The patients will be submitted to 5 minutes of upper limb compression by cuff followed by 5 minutes of reperfusion. This cycle will be repeated 4 times.
Hospital das Clínicas da Unicamp
Campinas, São Paulo, Brazil
RECRUITINGMolecular pathway activation
Time frame: 2 days
Inflammatory response
Time frame: 10 days
All cause of mortality
Time frame: 30 days
All cause of mortality
Time frame: 180 days
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