Bone Loss in Patients With Anorexia Nervosa

N/ACompletedNCT01907464

University Hospital, Montpellier320 enrolled

Overview

Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences. 160 patients (age \< 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

320

Conditions

Patients With Anorexia Nervosa

Interventions

clinical parameters descriptionOTHER

description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms

para clinical parameters descriptionOTHER

description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms

hormonal parameters dosingOTHER

dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms

Eligibility

Sex: FEMALEMin age: 14 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Informed Consent * Health Insurance regimen or benefit from an health insurance regimen * Aged from 14 to 38 years old * Women * No pregnant Specific inclusion criteria for patient: Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Specific inclusion criteria for controls: * Normal menstrual cycles, * No lifetime history of eating disorders, * BMI between 18 and 25 kg/m² Exclusion Criteria: * use of treatments may be modify bone mass (bisphosphonates,…) * Disease or treatment may be induce osteoporosis * In exclusion period in relation with another study * Law protected subject

Locations (1)

CHU de Montpellier - Département d'Endocrinologie Diabète

Montpellier, France

Outcomes

Primary Outcomes

Dual-X-ray absorptiometry (DEXA)

The primary outcome is to model the bone mass acquisition in young women with anorexia nervosa.

Time frame: at Day 0 (time of the inclusion visit)

Secondary Outcomes

Biological parameters identification

One of the secondary outcome is to identify biological factors associated with bone demineralisation.

Time frame: At day 0 (time of the inclusion visit)

clinical parameters identification

One of the secondary outcome is to identify the clinical factors associated with bone demineralisation.

Time frame: At Day 0 (at time of the the inclusion visit)

Data from ClinicalTrials.gov

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