A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence

Inclusion Criteria: * Subject is ≥ 18 years of age at time of consent * Subject must be able and willing to provide written informed consent * Subject must be able and willing to comply with the required follow-up schedule * Subject is a candidate for catheter ablation for the treatment of paroxysmal or persistent atrial fibrillation as per the hospital standard of care * Subject has office Systolic Blood Pressure ≥ 140 mmHg at baseline visit * Subject has a daytime mean Systolic Ambulatory Blood Pressure \> 135 mmHg within 90 days prior to procedure * Subject has established hypertension (diagnosed ≥12 month prior to baseline) and is taking \>3 anti-hypertensive medications, including 1 diuretic * Subject has been on a stable unchanged anti-hypertensive medication regimen for a minimum of 4 weeks prior to the ablation procedure Exclusion Criteria: * Subject has long standing atrial fibrillation * Subject has had a previous ablation for atrial fibrillation * Subject has had a previous renal denervation procedure * Subject has had a CABG procedure within the last 180 days (six months) * Subject has a left atrial thrombus * Subject has a contraindication to anticoagulation (i.e. heparin or warfarin) * Subject has unstable angina * Subject has had a myocardial infarction within the previous two months * Subject has a left ventricular ejection fraction (LVEF) \<40% as determined by pre-procedure TTE * Subject has significant renovascular abnormalities such as renal artery stenosis \> 30% * Subject has undergone prior renal angioplasty, renal denervation, indwelling renal stents, and/or abdominal aortic stent grafts * Subject has hemodynamically significant valvular heart disease as determined by study investigator * Subject has a life expectancy less than 12 months, as determined by the study investigator * Subject is participating in another clinical study which has the potential to impact his/her hypertension or atrial fibrillation management (pharmaceutical/device/homeopathic) * Subject is pregnant, nursing, or of childbearing potential and is not using adequate contraceptive methods * Subject has active systemic infection * Subject has renal arteries \< 4 mm in diameter * Subject has an estimated GFR \<45 mL/min per 1.73 m2 using the Modification of Diet in Renal Disease (MDRD) formula * Subject had a renal transplant or is awaiting a renal transplant * Subject has blood clotting or bleeding abnormalities * Subject has secondary arterial hypertension