Using Real-Time Functional Brain Imaging to Enhance Recovery From TBI

Inclusion Criteria: * Mild TBI: PTA/confusion≤1 hour immediately after injury; or LOC \<30 min \[69\] confirmed by the Ohio confirmed by the Ohio State University TBI Identification Method-Short Form (OSU TBI-ID-SF). * Age 18-45 years * Right handed \[70\]. * Minimum of 4 months and within 36 months post-injury * Can participate in fMRI and outcome assessment * Adequate visual, auditory, sensory-motor function for training program. * Fluent in English * Persistent cognitive dysfunction confirmed by an objective measure Exclusion Criteria: * History of hypoxic event * Pre-existing significant neurological (e.g. MS) or psychiatric (e.g. schizophrenia, bi-polar) disorders. * Current illicit drug use or ETOH abuse * Contraindications to MRI (metal, pregnant, pacemaker, claustrophobia, etc.). * Unwilling or unable (e.g. language barrier) to participate * Hospitalization during study * Current Med Board for discharge, Litigation/ + malingering test \[71\] * Use of medications to enhance cognitive function (e.g. Ritalin) * Initial Glascow Coma Score \<13 or penetrating head injury * Subjects must not show suicidal ideation as measured by the Columbia-Suicide Severity Rating Scale (C-SSRS; 111). Subjects with a score of 4 or 5 (as recommended by the FDA for treatment trials) will be excluded and referred for appropriate treatment. * Subjects should not be enrolled in a concurrent TBI clinical trial.