Normal pressure hydrocephalus diagnosis based on quantitative study of cerebro-spinal fluid and blood flow by phase contrast magnetic resonance imaging.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
144
Quantitative flow study was performed by 2D phase-contrast velocity-encoded cine MRI (repetition/echo time, 15/7 ms; field of view = 140 x 140 mm²; matrix size = 256 x 128, flip angle = 25 degrees,one excitation, slice thickness = 5 mm). Cerebrospinal fluid and blood flows are measured with a velocity-encoding value of 5-10 cm/s and 80 cm/s respectively. Peripheral gating was used to cover the entire cardiac cycle with retrospective cardiac synchronization of 32 quantitative flow-encoded images per cycle. Clinical examination consists in Larson's score and MMSE
CHU Lille
Lille, Hauts-de-France, France
CHU Amiens
Amiens, Picardie, France
cerebrospinal fluid (CSF) stroke volume evolution other 6 months
Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution
Time frame: Day 1 (baseline), Day 180
Blood flow analysis : evolution other 6 months
Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution.
Time frame: Day 1 (baseline), Day 180
Larson's score evolution over 6 months
Record symptoms on walking, living conditions and urinary disorders
Time frame: Day 1, Day 180
Neuropsychological test evolution over 6 months
Consists in mini mental status evaluation (MMSE) for cognitive evaluation
Time frame: Day1, Day 180
Blood flow analysis : evolution other one year
Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution.
Time frame: Day 1 (baseline) and Day 365
Larson's score evolution over one year
Record symptoms on walking, living conditions and urinary disorders
Time frame: Day 1 and Day 365
Neuropsychological test evolution over one year
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Consists in mini mental status evaluation (MMSE) for cognitive evaluation
Time frame: Day1, Day 365
cerebrospinal fluid (CSF) stroke volume evolution other one year
Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution
Time frame: Day1 (baseline), Day 365