Bioequivalence Study of Tacrobell Capsule 1mg to Prograf Capsule 1mg

Inclusion Criteria: * Signed the informed consent from prior to screening test * Between 19 years and 55 years in healthy male subject * Have not any congenital or chronic disease and medical symptoms * Body mass index(BMI) of 18 to 30 and a total body weight ≥ 55kg * Appropriate subject for the study judging from investigator Exclusion Criteria: * Evidence or history of clinically significant hepatic, renal, neurologic, immune system, respiratory system, endocrine * Any condition possibly affecting drug absorption (e.g. gastrectomy) * Subject with hypersensitivity to tacrolimus or any excipient * Administration of cyclosporin or bosentan * Administration of potassium-sparing diuretics * Subject with hereditary diseases of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption * SBP\<90 mmHg or DBP\<50 mmHg, SBP\>150 mmHg or DBP\>100 mmHg at least 3 minutes of rest * A positive HBsAg, HCV Ab, HIV Ab, RPR * AST, ALT \> 1.5\*upper limit of normal range at the screening test * Subject with a history of drug abuse or a positive reaction for drug abuse at the screening test * Taking ETC medicine including oriental medicine within 14days before the first hospitalization or taking OTC medicine, vitamin within 7days * Use of any drugs known to significantly induce or inhibit drug-metabolizing enzymes within 30 days prior to initiation test * Participating in a bioequivalence study or other clinical study within 3 month preceding the first hospitalization * Blood donation or more within 2 month or component blood donation within 1 month prior to the first hospitalization * Continued to be drinking(alcohol\> 21 units/week, 1 unit=10g of pure alcohol) or during clinical trials can not be drunk * Severe heavy smoker(cigarette\> 10 cigarettes/day) during 3 months or can not be smoking during the clinical study * Continued to be taking caffeine or can not be taken caffeine * Continued to be taking grapefruit or can not be taken grapefruit * Not use of contraception during the clinical study * An impossible one who participates in the clinical trial by investigator's decision including for reason of laboratory test result