Phase II Pilot Study Assessing Efficacy of a Cisplatin - Metronomic Cyclophosphamide Treatment in Patients With Metastatic Triple Negative Breast Cancer Resistant to Anthracyclines and Taxanes

Inclusion Criteria: * Age \> 18 ans, * Performance status \< 2, * Patient with metastatic breast cancer stade IV triple negative histologically confirmed * Measurable or not disease but radiologically evaluable (RECIST 1.1), * Negative Hormonal Receptors (Estrogens and/or Progesterone), HER-2 negative (Score 0 or 1 by Immunochemistry (IHC), negative FISH if score IHC 2), * Patient with a progression during or after an anthracyclines and/or taxanes treatment receiving in neo-adjuvant or adjuvant regimen according to a resistance defined as a documented disease progression in the last 12 month after the last dose of taxanes or anthracyclines, * Patient non previously treated by platinum salts, * Hematological Functions: Neutrophiles ≥ 1,5.109/L, Platelets ≥ 100.109/L, Leucocytes \> 3 000/mm3, Hb \> 9g/dL, * Hepatic Functions : total Bilirubin ≤ 1,5 time upper normal value (UNV), ASAT ≤ 2 ,5 time UNV, ALAT ≤ 2,5 time UNV, Alkaline Phosphatase ≤ 2,5 time UNV (\< 5 time UNV if case of hepatic metastasis), * Renal Functions: Creatinine Clearance ≥ 60 mL/min, * Patient signed the consent study form, * Patient affiliated to a social security regimen (law of 9 August 2004). Exclusion Criteria: * Male Patients, * Unknown hormonal Receptors * Positive HER-2 (Score 3 in IHC or positive FISH) * Pregnant or breastfeeding patient, or in age of pregnancy or predicting to be pregnant in the 6 months after the end of treatment, * Patient not using contraceptive treatment during the treatment or after the 6 months after the end of treatment, * Patient is a ward, * Patient suffering from a non compatible disease with the enrollment in the study, * Cardiac, renal, medullar, respiratory or hepatic insufficiency, clinically significant cardiovascular disease (including myocardiac infarct, unstable angina, symptomatic congestive heart failure, uncontrolled cardiac arrhythmia) \< 1 year before the study enrollment or randomisation, * Patient with pulmonary lymphangitis or symptomatic pleural effusion (grade≥2), meningeal known carcinoma or symptoms of cerebromeningeal invasion, brain metastases unless treatment and stability for at least 4 weeks (no steroids or anti-convulsive). * Uncontrolled diabetes, * Psychiatric or neurological significant abnormality, * Peripheric Neuropathy \> grade 2, * Antecedent of hypersensibility to one of study treatment or one of used excipients, * Urinary tract infection or acute hemorrhagic cystitis in progress * Concomitant treatment with a medicine containing phenytoin or medication received in the context of a trial, or participation in another therapeutic clinical trial within \<30 days prior treatment with chemotherapy. * Geographically unstable patient in the next 6 months or remaining distance to the treatment center making it difficult to follow in the study, * Known history of abuse of narcotic or other drug or alcohol * History of surgery within 28 days before the start of treatment, * Patient unwilling or unable to comply with the requirements of the study.