The purpose of this RCT is to learn more about how sounds that we experience in the womb can affect early development in premature infants. The investigators are specifically interested determining whether and what types of maternal sensory stimulation can influence physical growth, brain maturation, respiratory stability and early vocalization during postnatal development. The investigators hypothesize that daily exposure to biological maternal sounds, such as mother's voice and heartbeat, will improve both short-term and long-term developmental in premature infants and will increase their potential to grow into healthy children.
The purpose of this RCT is to learn more about how sounds that we experience in the womb can affect early development in premature infants. The investigators are specifically interested determining whether and what types of maternal auditory stimulation can influence physical growth, brain maturation, respiratory stability (including heart rate, respiratory rate and oxygen saturation levels) as well as early vocalization prior to 40 weeks gestation. The investigators hypothesize that daily exposure to biological maternal sounds, such as mother's voice and heartbeat, will improve both short-term and long-term developmental outcomes in premature infants and will increase their potential to grow into healthy children.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Brigham and Women's Hospital
Boston, Massachusetts, United States
RECRUITINGBrain volume (DM^3)
Data will be obtained by an MRI brain scan and will be calculated separately for white matter, grey matter, CSF.
Time frame: Between 36-40 weeks gestation
Language and cognitive skills
Data will be obtained using the MacArthur-Bates Communicative Development Inventories (CDI), the Receptive-Expressive Emergent Language Test Third Edition (REEL-3), and the Bayley Scales of Infant Development Third Edition (Bayley-III).
Time frame: At 12 and 24 months corrected-age
Oxygen saturation levels (mg/l)
Data will be collected from the bedside cardiac monitor
Time frame: participants will be followed for the duration of hospital stay, an expected average of 6 weeks
Heart rate (BPM)
Data will be collected from the bedside cardiac monitor
Time frame: participants will be followed for the duration of hospital stay, an expected average of 6 weeks
Infant vocalization (word count)
Data will be obtained by real-time recording of the language environment
Time frame: Between 32-36 weeks gesation
Weight gain (gr/kg/day)
Data will be obtained from medical records
Time frame: participants will be followed for the duration of hospital stay, an expected average of 6 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.