Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)

Inclusion Criteria: * Newborns ≥ 36 weeks gestation, \< 23 hours of age at time of consent, must meet all 3 Inclusion Criteria to be eligible for the study: 1. Perinatal depression = at least one of the following: a) Apgar ≤5 at 10 min or b) required resuscitation (endotracheal or mask ventilation, or chest compressions) at 10 min or c) pH \< 7.0 or base deficit ≥15 in cord, arterial, or venous blood obtained at \<60 min of age; 2. Moderate to severe encephalopathy = at least 3 of 6 modified Sarnat criteria present between 1-6 h of birth: a) reduced level of consciousness; b) decreased spontaneous activity; c) hypotonia; d) decreased suck; e) decreased Moro reflex; or f) respiratory distress including periodic breathing or apnea; and 3. Hypothermia = passive or active cooling begun by 6 hours of age. Exclusion Criteria: * Intrauterine growth restriction (BW \<1800 g); * Major congenital malformation; suspected genetic syndrome, metabolic disorder or TORCH infection; * Head circumference \< 2 SD for gestation; * Infant for whom withdrawal of supportive care is being considered; or * Anticipated inability to collect primary endpoint at 12 months of age.