The purpose of the study is to find out whether non-responsiveness to therapeutic recombinant human granulocyte colony-stimulation factor (rhG-CSF) is associated with hemophagocytosis in critically ill adult patients with cytopenias.
In children with bi- or pancytopenia, hemophagocytosis is known as life-threatening hemophagocytic lymphohistiocytosis (HLH). The purpose of the study is to find out whether adult patients with bicytopenia or pancytopenia fulfilling the clinical HLH criteria used in children reflect life-threatening hemophagocytosis and whether hemophagocytosis is associated with responsiveness to recombinant human granulocyte colony-stimulation factor (rhG-CSF) or not.
Study Type
OBSERVATIONAL
Enrollment
40
Department of Anaesthesiology, University Hospital Ulm
Ulm, Germany
RECRUITINGDepartment of Internal Medicine III, Comprehensive Infectious Disease Center, University Hospital Ulm, Germany
Ulm, Germany
RECRUITINGresponsiveness to recombinant human granulocyte colony-stimulating factor (rhG-CSF)
increase in leukocytes
Time frame: within 7 days
8 clinical HLH criteria
degree of fulfillment x out of 8 clinical HLH criteria
Time frame: 7 days
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