The Ranibizumab in Pigment Epithelium Tears Secondary To Age-Related Macular Degeneration (RIP) Study is a prospective, multicenter, uncontrolled, interventional phase 2 clinical trial that investigates the effect of fixed monthly intravitreal injections of ranibizumab (Lucentis, Novartis Pharma, Germany) on visual acuity and retinal morphology over a study period of 12 months in 30 patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
24
Monthly intravitreal injections
University of Bonn, Department of Ophthalmology
Bonn, Germany
University of München (LMU), Department of Ophthalmology
München, Germany
Universityof Münster, Department of Ophthalmology
Münster, Germany
Best-corrected Visual Acuity
Early Treatment of Diabetic Retinopathy Study (ETDRS) protocol
Time frame: 12 months
Retinal Morphology
Spectral-domain optical coherence tomography (SD-OCT) central retinal thickness
Time frame: 12 months
Vision-related Quality of Life
National Eye Institute Visual Function Questionaire 25-item version (NEI VFQ-25) 0 to 100 scale, where 100 represents the best possible score and 0 represents the worst Reference: Mangione CM et al. Arch Ophthalmol 2001 Jul;119(7):1050-8.
Time frame: 12 months
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