This is an observational, prospective study to evaluate the role of tranexamic acid in reducing blood transfusion in neonates undergoing cardiopulmonary bypass.
Study Type
OBSERVATIONAL
100mg/kg prior to incision, 100mg/kg on CPB and 100mg/kg after reversal of heparin with protamine.
Draw 20 mL/kg (up to 5Kg) of blood from patient and replace with washed PRBCs at 10-20mL/kg. (If \> 5Kg draw 20% of circulating blood volume without PRBC replacement)
Nationwide Children's Hospital
Columbus, Ohio, United States
Level of postoperative hemostasis
Evaluating the body's ability to stop or decrease postoperative bleeding.
Time frame: 24 hours
Volume of blood transfusions
Assessing the need for and amount of blood transfusions during the 1st 24 hours post-op.
Time frame: 24 hours
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