Blood Pressure Variability in Acute Ischemic Stroke

N/ACompletedNCT01915862

Aristotle University Of Thessaloniki353 enrolled

Overview

The purpose of this study is the evaluation and comparison of blood pressure variability indices and ambulatory arterial stiffness index obtained by ambulatory blood pressure monitoring as prognostic indicators in the functional outcome of acute ischemic stroke.

All consecutive patients admitted with acute (within 24 hours after stroke onset) ischemic stroke in three University Hospital of Northern and Central Greece will be included. Blood pressure measurements are being obtained with ambulatory 24-hour BP monitoring (ABPM) every 20 minutes within 24 hours of admission using automated oscillometric device (TM2430, A\&D Company Ltd) during day-time (7:00-22:59) and night-time (23:00-6:59). Several clinical, laboratory and imaging parameters are prospectively registered. Also, patients' medical history, previous medical treatment and cardiovascular risk factors are registered. Functional outcome is assessed by the modified Rankin Scale score at 3 months. Also, stroke recurrence and cardiovascular and all-cause mortality will be assessed.

Study Type

OBSERVATIONAL

Enrollment

353

Conditions

Ischemic Stroke

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute ischemic stroke * Admission within 24 after the onset of symptoms Exclusion Criteria: * Transient ischemic attack * Intracerebral hemorrhage * Subarachnoid hemorrhage * Cerebral sinus venous thrombosis * Stroke mimics * Late admission (\>24 hours after stroke onset)

Locations (3)

Second Department of Internal Medicine, Medical School, University of Ioannina, University Hospital of Ioannina

Ioannina, Greece

Department of Medicine, Medical School, University of Thessaly, University Hospital of Larissa

Larissa, Greece

First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital

Thessaloniki, Greece

Outcomes

Primary Outcomes

Modified Rankin Scale Score (mRS)

Description (score) * No symptoms at all (0) * No significant disability despite symptoms; able to carry out all usual duties and activities (1) * Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance (2) * Moderate disability; requiring some help, but able to walk without assistance (3) * Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance (4) * Severe disability; bedridden, incontinent and requiring constant nursing care and attention(5) * Dead (6)

Time frame: Three months (90 days)

Data from ClinicalTrials.gov

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