The aim of this study is to determine whether high high density lipoprotein-cholesterol(HDL-C) level and low Cholesteryl Ester Transfer Protein(CETP) activity is atherogenic or not in subjects who received health checkups. We investigate the association between CETP activities and the severity of atherosclerosis assessed by intima-media thickness (IMT) and compare the atherogenic change between in subjects with high HDL-C level, low HDL-C level, high CETP activities and low CETP activities by examining the morbidity rate of atherogenic diseases, the rate of ischemic electrocardiography(ECG) change, Calc Score of artery from chest X-ray, Ankle Brachial Index/Pulse Wave Velocity and various serum atherogenic markers. And we also examine the correlation between normal lipid profile and concentration, activity and function of surface lipoprotein in subjects with variety of lipoprotein levels, including patients with hyper-LDL-cholesterolemia, hyper-HDL-cholesterolemia with low or no CETP activity, patients with high level of remnant cholesterol or hyperlipoproteinemia of apolipoprotein(Apo)B-48.
Study Type
OBSERVATIONAL
Enrollment
1,500
Osaka University Graduate School of Medicine
Suita, Osaka, Japan
RECRUITINGDifference of Ischemic changes of ECG among subjects with low/high CETP mass/activity and HDL-C level
The difference of Ischemic changes of ECG was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Calc Score of Aorta by Chest X-ray among subjects with low/high CETP mass/activity and HDL-C level
The difference of Calc Score of Aorta by Chest X-ray was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Ankle Brachial Index (ABI) among subjects with low/high CETP mass/activity and HDL-C level
The difference of Ankle Brachial Index (ABI) was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Pulse Wave Velocity (baPW) among subjects with low/high CETP mass/activity and HDL-C level
The difference of Pulse Wave Velocity (baPW) was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of IMT and Plaque Score of Carotid artery among subjects with low/high CETP mass/activity and HDL-C level
The difference of IMT and Plaque Score of Carotid artery was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of CETP activity between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of CETP activity was assessed between in those who do not satisfy any of these three conditions (normolipidemic subjects) and those who satisfy any of these three conditions (patients with dyslipidemia); LDL-C:100 mg/dl and above, HDL:80 mg/dl and above, TG:150 mg/dl and above.
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Antioxidant activity between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of Antioxidant activity was assessed between normolipidemic subjects and patients with dyslipidemia;HDL from subjects' serum samples will be added to LDL with 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH).
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Monocyte chemoattractant protein-1 (MCP-1) concentration between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of MCP-1 concentration was assessed between normolipidemic subjects and patients with dyslipidemia
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Cholesterol efflux between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of Cholesterol efflux by HDL from macrophage was assessed between normolipidemic subjects and patients with dyslipidemia
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Proteome analysis of lipoproteins between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of Proteome analysis of lipoproteins (HDL, LDL, remnant binding protein) was assessed between normolipidemic subjects and patients with dyslipidemia
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Fasting blood glucose and HbA1c among subjects with low/high CETP mass/activity and HDL-C level
The difference of Fasting blood glucose and HbA1c was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of waist circumference among subjects with low/high CETP mass/activity and HDL-C level
The difference of waist circumference was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Smoking habits, alcohol taking habits and fitness habits among subjects with low/high CETP mass/activity and HDL-C level
The difference of Smoking habits, alcohol taking habits and fitness habits was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of BMI among subjects with low/high CETP mass/activity and HDL-C level
The difference of BMI was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Blood Pressure among subjects with low/high CETP mass/activity and HDL-C level
The difference of Blood Pressure was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
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Difference of 75g glucose tolerance test and calculated homeostasis model assessment of insulin resistance (HOMA-IR) among subjects with low/high CETP mass/activity and HDL-C level
The difference of 75g glucose tolerance test and calculated homeostasis model assessment of insulin resistance (HOMA-IR) was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Total Cholesterol(TC) among subjects with low/high CETP mass/activity and HDL-C level
The difference of Total Cholesterol(TC) was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of low density lipoprotein-cholesterol (LDL-C) among subjects with low/high CETP mass/activity and HDL-C level
The difference of low density lipoprotein-cholesterol (LDL-C) was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of triglyceride (TG) among subjects with low/high CETP mass/activity and HDL-C level
The difference of triglyceride (TG) was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Serum adiponectin among subjects with low/high CETP mass/activity and HDL-C level
The difference ofSerum adiponectin was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Apolipoprotein (apo)B-48 concentrations among subjects with low/high CETP mass/activity and HDL-C level
The difference of Apolipoprotein (apo)B-48 concentrations was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Remnant lipoprotein (RemL-C) among subjects with low/high CETP mass/activity and HDL-C level
The difference of Remnant lipoprotein (RemL-C) was assessed between in subjects with high CETP mass/activity and in those with low CETP mass/activity, and between in subjects with high HDL-C level and in those with low HDL-C level
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Lipoprotein Profile between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of Lipoprotein Profile analyzed by high performance liquid chromatography(HPLC) method was assessed between in those who do not satisfy any of these three conditions (normolipidemic subjects) and those who satisfy any of these three conditions (patients with dyslipidemia); LDL-C:100 mg/dl and above, HDL:80 mg/dl and above, TG:150 mg/dl and above.
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of apolipoprotein(apo)B-48 concentrations between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of apoB-48 concentrations was assessed between in normolipidemic subjects and in patients with dyslipidemia
Time frame: participants will be followed for the duration of hospital stay（2 days）
Difference of Remnant lipoprotein (RemL-C) between normolipidemic subjects and patients with dyslipidemia (including high HDL-C level)
The difference of RemL-C was assessed between in normolipidemic subjects and in patients with dyslipidemia
Time frame: participants will be followed for the duration of hospital stay（2 days）