A Dose-response Study of Lidocaine and Etomidate

Phase 1CompletedNCT01916642

West China Hospital100 enrolled

Overview

IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.

The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

100

Conditions

Etomidate Overdose of Undetermined Intent

Interventions

Lidocaine 1mg/kgDRUG

The total dosage of Etomidate needed for induction of anesthesia is recorded at last.

Lidocaine 1.5mg/kgDRUG

same as other

Lidocaine 2mg/kgDRUG

same as other

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients scheduled for Elective Surgery, 2. age limit within 18-70 years, 3. American Society of Anaesthesiologists physical status classification I-II Exclusion Criteria: 1. Adrenal Cortex disorder, 2. Neurologic disease, 3. Psychiatric disorders, 4. Allergic to Local anesthetic drugs, 5. Patients who have received sedatives,analgesics or opioids within the previous 24 hrs.

Outcomes

Primary Outcomes

changes in blood pressure and heart rate.

Time frame: 6 weeks

Data from ClinicalTrials.gov

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