Weight Based Enoxaparin in Trauma Patients

Inclusion Criteria: * 18 years of age or older * Body Weight \>60 kg * Admitted to the trauma services at Intermountain Medical Center * Have received 1 standard dose of enoxaparin for VTE prophylaxis during current hospital admission. Exclusion Criteria: * Significant bleeding injury such as solid organ laceration or intracranial bleed at discretion of attending physician * Renal insufficiency (GFR \<30) * Platelet count \<100 thousand per cubic ml * Hypersensitivity to heparin or prior documented heparin induced thrombocytopenia (HIT) by patient report or in medical record * Pregnant or breast feeding * Hemorrhagic stroke in proceeding 3 months * abnormal baseline coagulation characterized by an INR \>1.4, obtained at the discretion of the treating clinician * Required therapeutic anticoagulation for atrial fibrillation, prior VTE, or mechanical heart valve * Treatment with concomitant antiplatelet agent other than aspirin 326 mg or more daily * Subjects with a life expectancy less than 1 month * Subjects hospitalized more than 72 hours prior to randomization.