Effect of Octreotide on the Colonic Motility in Pediatric Patients

Inclusion Criteria: * Male or female and undergoing colonic manometry for a routinely accepted indication including: evaluation of chronic constipation, unexplained abdominal distension (Should have had previous diagnostic work up), recurrent fecal impaction, post Hirschsprung's disease repair, chronic intestinal pseudo-obstruction, or suspected colonic dysmotility of any other cause. * Children aged 12 months or older who are undergoing colonic motility under the supervision of Dr. Joseph Croffie at Riley Hospital. * In the investigator's judgment, parent(s)/guardian(s) is mentally competent to provide informed consent to participate in the study. Exclusion Criteria: * • Subjects with known or suspected allergy to octreotide. * Subjects with known prolonged corrected QT interval (QTc) Syndrome or highest risk QTc-Prolonging Agents (including mifepristone). * Subjects with known history of ventricular arrhythmia. * Subjects with history of any organ transplant who are taking cyclosporine at the time of the motility study. * Subjects with history of small bowel transplant. * Subjects less than 12 months old. * Subjects with severe renal impairment * Subjects with severe hepatic impairment * Subjects taking bromocriptine, insulin, oral hypoglycemic agents, beta blockers, calcium channel blockers, quinidine, terfenadine, pimozide, sildenafil, tadalafil, and any agents to control fluid and electrolyte imbalance