Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Trial From RENEWAL RDN Registry)

Inclusion Criteria: * Patients aged 20-85 years with resistant hypertension defined as systolic BP\>140 mmHg (\>130 mmHg for diabetes) or diastolic BP\>90mmHg (\>80 mmHg for diabetes) despite adequate administration of 3 or more different classes of anti-hypertensive medications including diuretics with good adherence and adequate treatment regimen. * All agents should be prescribed at optimal dose amounts. BP was based on an average of 3 office BP readings measured according to the general guidelines. Patients are adhering to a stable drug regimen including 3 or more antihypertensive medications (with no changes for a minimum of 2 weeks prior to enrollment). * Patients provided with the written, informed consent to participate in this study Exclusion Criteria: * Hemodynamically or anatomically significant renal artery abnormalities, main renal arteries \< 4 mm in diameter or \< 20 mm in length, or.prior renal artery intervention * Estimated glomerular filtration rate (eGFR) of \< 30mL/min/1.73m2, using the MDRD calculation * Hemodynamically significant valvular heart disease * History of congestive heart failure with reduce LV ejection fraction of less than 35% * CVA in the prior 3 months * ST-segment elevation MI within 48 hours * Scheduled or planned surgery or cardiovascular intervention in the next 6 months. * Patients with chronic debilitating disease with life expectancy of less than 1 year * Patients taking hormone replace treatment and/or oral contraceptives; pregnant, nursing or planning to be pregnant * Chronic liver cirrhosis