The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity

N/ACompletedNCT01918566

University Hospital, Basel, Switzerland12 enrolled

Overview

Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Exploratory Behavior

Interventions

tap waterDIETARY_SUPPLEMENT

Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tubeDIETARY_SUPPLEMENT

Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisoleDIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * right-handed healthy males, no drugs, non-smoking Exclusion Criteria: * drug abuse, smoker, left-handed, claustrophobia

Locations (1)

University Hospital

Basel, Switzerland

Outcomes

Primary Outcomes

Functional magnetic resonance imaging (fMRI) in healthy volunteers while they performed a working memory task: changes in cerebral blood flow and blood hormones from baseline to treatment

Whole brain analysis with a cluster-level threshold was followed by an a priori defined region of interest analysis of the dorsolateral prefrontal cortex including a cluster-level threshold and family-wise error adjustment for multiple comparisons.

Time frame: changes from baseline to one hour after treatment

Data from ClinicalTrials.gov

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