Renal Effects of Levosimendan in Cardiac Surgery Patients

N/ACompletedNCT01918618

Charite University, Berlin, Germany92 enrolled

Overview

Recent experimental and clinical data suggest a benefit of levosimendan on the kidney function. Therefore, this retrospective, single center, matched-pairs analysis aimed to investigate whether administration of levosimendan was associated with improved renal function in cardiac surgery patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Treatment of Left Heart Insufficiency in an Operative Setting of Cardiac Surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing cardiac surgery (OPS 5-35 bis 5-37) between 2007 and 2011 followed by postoperative observation on an ICU of the anaesthesiology department of the Charité hospital Exclusion Criteria: * Patients younger 18 * Preexisting renal insufficiency

Locations (1)

Charité - University Medicine Berlin

Berlin, State of Berlin, Germany

Outcomes

Primary Outcomes

Change of plasma creatinine (Difference in renal function)

Only in patients not requiring renal replacement therapy

Time frame: last available value pre-op (baseline), first available value on post-op day 1, 2, 3 and 4

Change of urine output after surgery (difference in renal function)

Only in patients not requiring renal replacement therapy

Time frame: post-op day 1, 2, 3, 4

Cumulative incidence and duration of hemodialysis (Difference in renal function)

Time frame: last day of hospital stay

Secondary Outcomes

Cumulative Length of stay (hospital and ICU)

Time frame: last day of hospital stay

In-hospital mortality

Time frame: last day of hospital stay

Data from ClinicalTrials.gov

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