Efficacy and Safety of Injection With VINCI Plus Hyaluronic Acid Filler

Inclusion Criteria: * Male or female between the ages of 30-65, at the point of screening, wrinkles on both sides of treatment area (nasolabial fold) are in the 3rd or 4th level on the WSRS(Wrinkle Severity Rating Score) * Surrounding soft tissue of wrinkles on both sides of nose and lips are sagging * Wrinkles of both sides of nose and lips are visually symmetric * Agrees to stop all other treatment of facial wrinkle improvement including dermatology treatment during clinical trial * Able to understand and follow instructions and participate the entire period of the clinical trial * Subject voluntarily agrees to participate in clinical trial and gives informed written consent Exclusion Criteria: * At the point of screening, intradermal test results show skin irritation to medical devices of clinical trial * Within 2 weeks before the date of screening, subject has taken antithrombotic (with the exception of low dose aspirin 100mg, up to 300mg/day) or non-steroidal anti-inflammatory medication * Case where subject has abnormal liver function or blood coagulation, has to take antithrombotic medication (with the exception of low dose aspirin 100mg, up to 300mg/day) during clinical trial * Subject has used facial topical liniment (steroids, retinoids: excluding only medicines and cosmetics) within 4 weeks before date of screening or plans to continue using facial topical liniment during clinical trial * Within 6 months before date of screening, subject has received anti-wrinkle or acne treatment * Within 6 months before date of screening, subject has received facial microdermabrasion treatment, skin regeneration/rejuvenation treatment, plastic surgery, or cosmetic surgery (including Botox injections) * Within 1 year before date of screening, subject has received CaHA (Calcium Hydroxyapatite) treatment on clinical trial medical device treatment area * Subject has cured facial gel (Softform) or silicone implants inserted as permanent facial expansion * Within 1 year before, subject had an illness that caused scarring or has scars on clinical trial medical device treatment area * Subject has facial skin disease or skin wound infection that affects the clinical trial * Weak immune system or suspect that the immune system is weak * History of anaphylaxis or severe allergic complexity * History of hypertrophic scar or keloid * In the past, if there were adverse effects from EMLA Cream (if EMLA Cream was not used, the exclusion criteria for subjects applicable) * History of hypersensitivity to Lidocaine * Cardiovascular, digestive, respiratory, endocrine, central nervous system disorders that seems clinically significant or had a mental illness that had a significant impact on a previous clinical trial or currently has a mental illness * Within 30 days before screening, subject participated in other clinical trials * Female subjects of childbearing potential does not agree to a medically accepted method of contraception for the period of the clinical trial Medically acceptable methods of contraception: condoms; oral contraception continued for at least three months; or if intrauterine is used, installed a contraceptive device * Pregnant women or nursing mothers * In addition to the above, the test director or person in charge medically judges there are clinically significant findings that are improper for the clinical trial