Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies

N/AUnknownNCT01919957

Institut National de la Santé Et de la Recherche Médicale, France120 enrolled

Overview

This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies. Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

120

Conditions

Epilepsy, Unspecified, Pharmacologically Resistant Memory Impairment

Interventions

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with drug-resistant epilepsy * Age of 18 years or more * Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital * Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment * Covered by a social security system * Signing of consent form Exclusion Criteria: * Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom * Refusal to consent form * Contraindications to MRI * Pregnancy * Refusal to be informed in the case of detection of an abnormality during the experiment

Outcomes

Primary Outcomes

Measure of successfull encoding

Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI

Time frame: 8 years

Central Contacts

Sophie DUPONT, MD, PhD

CONTACT

01 42 17 85 23 sophie.dupont@psl.aphp.fr

Virginie LAMBRECQ, MD