Adequate, safe sedation is essential for Endoscopic submucosal dissection. Dexmedetomidine is a potent and selective a2-adrenoceptor agonist used for sedative and analgesic effects, but it is limited to use alone. The investigators designed this study to compare the effect and safety of two sedatives, dexmedetomidine and propofol in Endoscopic Submucosal Dissection (ESD), when sufficient analgesia-remifentanil is administered all throughout the procedure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Anesthesiology & Pain Medicine, Yonsei university college of medicine
Seoul, South Korea
A comparison of safety during endoscopic submucosal dissection between dexmedetomidine-remifentanil and propofol-remifentanil
Safety : whether the complications as follows occur or not 1. systolic blood pressure under 90mmHg or 20% out of range of the baseline SBP 2. heart rate under 50bpm 3. oxygen saturation under 90%, respiratory rate under 7 per minute
Time frame: right after the drugs had administered
A comparison of efficacy during endoscopic submucosal dissection between dexmedetomidine-remifentanil and propofol-remifentanil
Efficacy : 1. whether a bolus injection of 10 mg of propofol was administered or not 2. evaluating the depth of sedation using MOAA/S scale all through the procedure 3. whether the en bloc resection, complete resection were done or not under the sedation
Time frame: right after the drugs had administered
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