Dexmedetomidine on Pediatric Heart Operation

N/ACompletedNCT01920542

Gachon University Gil Medical Center30 enrolled

Overview

we hypothized dexmedetomidine could reduce the reduction of renal function after cardiopulmonary bypass weaning in pediatric patients

dexmedetomidine, a2-adrenoreceptor agonist has been used for sedation or hemodynamic stability for operative procedure. It had been already reported that dexmedetomidine reduce the impairment of renal functon after cardiac operation in adult. we hypothized dexmedetomidine could reduce the reduction of renal function after cardiopulmonary bypass weaning in pediatric patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Acute Renal Injury

Interventions

DexmedetomidineDRUG

administration of dexmedetomidine on dexemedetomidine group

no dexmedetomidineDRUG

no administration of dexmedetomidine on control group

Eligibility

Sex: ALLMin age: 1 YearMax age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1-6yr pediatric cardiac patients Exclusion Criteria: * previous renal dysfunction

Locations (1)

Gachon University Gil Medical Cneter

Incheon, South Korea

Outcomes

Primary Outcomes

renal function

at immediate after anesthetic induction (baseline), after weaning of cardiopulmonary bypass, 2h after end of operationCPB, sodium and creatinine in the urine and serum, N-acetyl-b-glucosaminidase (NAG)and albumin in only urine could be studied

Time frame: from anesthetic induction up to postoperative 2h

Data from ClinicalTrials.gov

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