Metabolomics of Liver Regeneration Following Partial Hepatectomy in Healthy Living Liver Donors

N/ACompletedNCT01922323

Baylor Research Institute20 enrolled

Overview

The PI will study metabolism during liver regeneration in living liver donors

Samples of blood and urine will be collected from study participants at defined timepoints. The samples will be evaluated to study the metabolism of the regenerating liver after a portion of the liver has been donated from a living donor.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Insufficiency

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Potential donor must be in excellent medical and psychological health. 2. Potential donor must be between the ages of 18 and 60. 3. Must have a compatible blood type to the recipient. 4. Must have health care coverage for non-donor related health issues that arise post donation 5. Recipient and donor must have compatible body size. 6. Donors Body Mass Index (BMI) must be less than 30. 7. All previous donor abdominal surgeries will be reviewed on a case by case basis by the surgeon. Exclusion Criteria: 1. Positive blood test for Human Immunodeficiency Virus, Hepatitis C virus, Hepatitis B virus 2. The size of the donor liver is not large enough to safely resection and still retain enough volume to function normally after the surgery. 3. Liver biopsy show liver cirrhosis or early stages of HCC. \- \-

Locations (1)

Baylor University Medical Center

Dallas, Texas, United States

Outcomes

Primary Outcomes

Characterized Metabolic Changes during liver regeneration

Time frame: one year after donation

Data from ClinicalTrials.gov

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