Although deep brain stimulation of the subthalamic nucleus(STN DBS) has become the surgical treatment of choice for Parkinson's disease(PD), a consensus on the timing of surgery is lacking. This study is intended to demonstrate that early, compared with delayed, introduction of STN DBS is more beneficial for PD patients who have developed motor complications.
In this prospective study, 200 PD patients will be recruited for STN DBS over three years, including 133 with motor complications existing for more than three years (late complication group) and 67 less than three years (early complication group). To make a comparison of therapeutic efficacy between the two groups, motor and non-motor symptoms will be assessed using specific rating scales and questionnaires.
Study Type
OBSERVATIONAL
Enrollment
200
the First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Changes in 39-item Parkinson's disease questionnaire (PDQ-39) scores
Quality of life
Time frame: From baseline to 4 years
Changes in Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III scores
Motor function
Time frame: From baseline to 4 years
Changes in time spent in the "on" state without troubling dyskinesia based on Parkinson's disease home diary
Good "on" time
Time frame: From baseline to 4 years
Changes in MDS-UPDRS patient questionnaire (Part I B and Part II) scores
Motor and non-motor experiences of daily living
Time frame: From baseline to 4 years
Severe adverse effects
Safety profile
Time frame: From baseline to 4 years
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