If we compare eradication rate of Helicobacter pylori divided to 4 groups: amoxicillin, rabeprazole, clarithromycin(AOC), amoxicillin, rabeprazole, metronidazole(AOM), treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days(sequential), amoxicillin, clarithromycin, metronidazole, rabeprazole(concomitant), then the eradication rate of concomitant group will be the highest.
* Subject: The patient of gastritis, gastric ulcer, and duodenal ulcer infected with Helicobacter pylori * 170 subjects per group * Eradication regimens are as follows: AOC group, treated with amoxicillin, rabeprazole, clarithromycin for 7 days; AOM group, treated with amoxicillin, rabeprazole, metronidazole for 7 days; sequential group, treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days; concomitant group, treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
540
Yeouido St. Mary's Hospital
Seoul, South Korea
RECRUITINGEvaluation of the efficacy of concomitant therapy for eradication of Helicobacter pylori
measure eradication rate of H.pylori with urea breath test(UBT) after 6 to 8 weeks of treatment
Time frame: 6 months (Feb 2014)
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