Study of Genic Expression Profiles of the Epithelium of the Nose and Bronchi in Healthy and Allergic Subjects

N/ACompletedNCT01923519

Centre Hospitalier Universitaire de Nice44 enrolled

Overview

The respiratory epithelium plays a leading role in the development of allergic respiratory disease with barrier function alteration, its repair mechanisms, of anti-viral fight and the ability to induce by itself Th2 responses. The majority of allergic asthmatic patients have reached concomitant ENT: the concept of "one airway, one disease." Access to this material of epithelial study in the different phenotypes of the disease appears to be crucial. Nasal and bronchial epithelial tissues reveal essential differences in particular related to their environment (remodeling less intense and a lower sensitivity to the virus in the nose), but they nevertheless share many common cellular characteristics.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Enrollment

Conditions

Allergy

Interventions

bronchofiberscopyPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥ 18 years and \<30 years * isolated allergic rhinitis according to clinical criteria ARIA * absence of asthma whose diagnosis is made based on clinical criteria or mild to moderate persistent asthma controlled with a diagnosis is made based on clinical criteria Exclusion Criteria: * recent rhino-bronchial infection (\<6 weeks) * asthma exacerbation in the previous 6 weeks * Chronic disease may in the opinion of the investigators interfere with the results of the study or expose them to additional risk. * Treatment with nasal corticosteroids, inhaled or systemic in the past 6 weeks * Current smoking no history of smoking or not smoking for at least 12 months and weaned smoking history \<5 pack-years) * Special Needs

Study of Genic Expression Profiles of the Epithelium of the Nose and Bronchi in Healthy and Allergic Subjects

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes