Phase II Study of DA-3031(PEG-G-CSF) in Chemotherapy-induced Neutropenia

Inclusion Criteria: 1. Diagnosis of stage II or III breast cancer 2. Age : ≥18, ≤70 3. TAC regimen as adjuvant therapy 4. ANC≥1,500/mm3, Platelet≥100,000/mm3, ECOG : 0 or 1 5. Creatinine \< 1.5 x ULN 6. Total bilirubin/AST/ALT \< 1.5 x ULN, ALP \< 2.5 x ULN 7. Have given a written, informed consent Exclusion Criteria: 1. Received any other investigational drugs within 30 days of informed consent date 2. Received systemic antibiotics within 72 hours of chemotherapy into this study or Radiation therapy within 4 weeks of informed consent date 3. Infective symptom before chemotherapy into this study 4. Pregnant or lactating women 5. Prior bone marrow or stem cell transplantation 6. Other malignancy history within 5 years 7. HIV positive 8. Prior exposure to pegfilgrastim or filgrastim or other colony-stimulating factors within 6 weeks of informed consent date 9. Prior chemotherapy