A Short-term Comparative Study of Aerosure for Airway Clearance in Patients With Cystic Fibrosis

Inclusion Criteria: * A diagnosis of CF (established by genotype or sweat sodium \>70mmol/l or sweat chloride of \>60 mmol/l * Admitted to King's College Hospital within 48 hours of an acute infective pulmonary exacerbation characterised by an increase in respiratory symptoms requiring intravenous antibiotics Exclusion Criteria: * Acute respiratory failure * Haemodynamic instability (including severe right heart failure with hypotension) * Current severe haemoptysis * Ineffective cough * Rib fractures * Pregnancy * Current or recent pneumothorax * Epilepsy * Current pulmonary embolism * Oesophageal varices * Recent thoracic upper gastro-intestinal tract or facial surgery * Active tuberculosis * Recent brain, eye, ear, ENT surgery * Myocardial infarction * Ascending aortic aneurysm * Acute diarrhoea * Pulmonary embolism * Angina * Severe hypertension (systolic \>200 mm Hg, diastolic \>120 mm Hg) * Confusion/dementia * Inability to give consent