Pregabalin 150mg or placebo are administered 1 hour preoperatively in patients undergoing partial hepatectomy. Postoperatively, patients receive morphine as rescue analgesic. Morphine consumption in the first 48 hours is documented. Postoperative pain is measured by the visual analogue scale (VAS) score.
Methods: In this Randomized Controlled Trial, patients undergoing partial hepatectomy will be administered a single pre-operative dose of Pregabalin or a placebo. Primary endpoints are as follows: * Post-operative analgesic requirements * Post-operative VAS scale (rated 0-10) * Complications * Post-operative antiemetic requirement * Length of stay
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
One 150 mg oral dose of Pregabalin given before surgery
One oral dose of placebo given before surgery
Eastern Hepatobiliary Surgery Hospital
Shanghai, China
Postoperative Opioid Consumption
Time frame: 48 hours
Postoperative Pain Scores on the Visual Analog Scale
Time frame: 24 hours
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