Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

N/ACompletedNCT01924221

Johns Hopkins University31 enrolled

Overview

Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Failure Patients Undergoing CRT-D Device Implantation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing implantation of a CRT-D Exclusion Criteria: * age \< 18 y * pregnancy or planned pregnancy

Locations (1)

Johns Hopkins Hospital

Outcomes

Primary Outcomes

correlation between electrical and mechanical remodeling

correlation between electrical and mechanical measures of dyssynchrony

Time frame: 6 months after CRT implantation