Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury

N/ACompletedNCT01924663

University of Saskatchewan21 enrolled

Overview

The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus, metapneumovirus, parainfluenza, influenza, etc.) in pediatric patients.

This is a single-centre, prospective and retrospective, descriptive data-collection pilot study. Prospective Data Collection: All pediatric patients who are less than 18 years with a confirmed positive respiratory viral swab will be invited to participate. Retrospective Data Collection: The retrospective portion of this study will examine a 5 year period prior to the start of enrollment for the prospective study, with the intention to include all pediatric patients who are less than 18 years with a confirmed positive respiratory viral swab and admitted into the local hospital's PICU.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Failure Acute Kidney Injury

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. The parent or legal guardian of the pediatric subject must sign the Consent Form for participants in the prospective portion of the study. 2. The subject must be no greater than 18 years of age, at the time of consent. 3. The subject must be admitted to the local hospital. 4. The subject must have a confirmed positive respiratory viral swab. Exclusion Criteria: 1. The parent or legal guardian of the pediatric subject is unavailable or unwilling to sign the Consent Form for participants in the prospective portion of the study. 2. The subject has had previous kidney injury or myocardial dysfunction prior to positive respiratory viral swab. 3. The subject has any previous problems (prior to positive respiratory viral swab) with their heart or kidneys that could compromise the results, in the opinion of the Investigator.

Locations (1)

Royal University Hospital

Saskatoon, Saskatchewan, Canada

Outcomes

Primary Outcomes

Myocardial dysfunction, as defined by a low ejection fraction on an Echocardiogram.

Time frame: up to 7 days

Acute Kidney Injury (AKI) as defined by the meeting of the pediatric RIFLE criteria.

Time frame: up to 7 days

Data from ClinicalTrials.gov

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