Among the patients with coronary heart disease, those with ACS (acute coronary syndrome) are extremely high-risk patients. Therefore, management outside hospital, especially the regular administration of drugs, is vital to prevent the recurrence of cardiovascular events. However, most patients often fail to stay on a long-term administration regimen, especially the administration of statins. According to the statistics, the average duration adhered with statin in patients with ACS is less than 3 months, use of statin at hospital discharge was only 80% and 65% in 6 month, with a very low LDL-C control rate (about 11% at 6 months), which poses a threat to the recurrence rate of cardiovascular events in patients with ACS. It was found in previous studies that there were many factors influencing patients' compliance, in which patients' refusing to take medicine accounted for a higher proportion. It suggests that patient had not recognized the importance of long-term administration. Therefore, it is extremely important for physicians to strengthen patient education and regular follow-up visits during disease management. Moreover, the effectiveness of patient education during chronic disease management has already been proved in some studies abroad, and the interventional effect of multiple patient education process outweighs that of single approach education. Thus, we intend to conduct a randomized and controlled study to explore the effect of multi-channel intensive patient education on LDL-C target achieving rate and statin adherence in patients with ACS in China.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
2,568
Statin Treatment:The investigator will be suggested to increase the dose of atorvastatin according to guideline if a patient's LDL-C does not achieve target level. Patient education: 1. Routine education at discharge. 2. 4 education brochures will be delivered to patients. 3. Calendar with healthy tips will be delivered to patients before discharge. 4. A follow-up brochure with medical expert letter. 5. A total of 24 specific short messages for ACS will be developed and sent to patients (one short message per week). 6. Telephone follow ups will be performed according to a standard communication document. At discharge, patients will be given a brochure for future follow up.
Statin Treatment:The recommended dosage of atorvastatin will be adjusted at the physician's discretion. Patient education: 1. Routine education at discharge. 2. A follow-up brochure without medical expert letter. At discharge, patients will be given a brochure for future follow up.
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
The 2nd affiliated hospital of harbin medical university
Harbin, Heilongjiang, China
Xi'an Jiaotong University College of Medicine
Xi’an, Shanxi, China
The Luhe Teaching Hospital of the Capital Medical University
Beijing, China
Shanghai Zhongshan Hospital
Shanghai, China
LDL-C target achieving rate
Time frame: at Week 24 post-discharge
LDL-C target achieving rate
Time frame: at Week 12 post-discharge
the proportions of patients with statin persistence
Time frame: at Week 12 post-discharge
the proportions of patients with statin persistence
Time frame: at Week 24 post-discharge
statin compliance
Time frame: at Week 12 post-discharge
statin compliance
Time frame: at Week 24 post-discharge
the relationship of LDL-C target achieving rate and statin compliance
Time frame: at Week 24 post-discharge
the discontinuation reason of statin therapy
Time frame: at Week 24 post-discharge
the difference of LDL-C control rate and statin compliance
To find the difference of LDL-C control rate and statin compliance between pre-specified sub-groups: PCI or non-PCI/male or female/age (≥65) or not/ having medical insurance or not/dyslipidemia history or not /MI (myocardial infarction) or UA (unstable angina)/different risk level according to TIMI/ patients for first consulting or patients with recurrence/ have received statin in the last 3 months or not.
Time frame: at Week 24 post-discharge
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